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Optimizing Your Cells' Detoxification/Cleansing Ability by Eating Cabbage and Other Cruciferous Veg

Optimizing your cells' detoxification/cleansing ability is easy—simply enjoy a serving of cruciferous vegetables several times each week.

One of the most exciting recent developments in our understanding of the ways in which our environment interacts with our genes to produce health or disease is the discovery that cruciferous vegetables—like broccoli, cauliflower, kale, red and green cabbage, mustard greens, collard greens and Brussels sprouts—provide phytonutrients that increase our ability to cleanse/detoxify and eliminate harmful compounds from our body.

For about 20 years, we have known that phytonutrients protect our health by working as antioxidants to disarm free radicals before they can damage DNA, cell membranes and fat-containing molecules such as cholesterol. Now, we're learning that phytonutrients in crucifers work at a much deeper level. These compounds actually signal our genes to increase production of enzymes involved in detoxification, the cleansing process through which our bodies eliminate harmful compounds.

Furthermore, we now know that whole foods provide not just one or two phytonutrients that work like lone agents, but phytonutrient combinations whose effects are synergistic.

The phytonutrients in cruciferous vegetables initiate an intricate dance inside our cells in which gene response elements direct and balance the steps among dozens of partners, each performing its own protective role in perfect balance with the other dancers. The natural synergy that results optimizes our cells' ability to disarm and clear free radicals and toxins, including potential carcinogens, which may be why crucifers appear to lower our risk of cancer more effectively than any other vegetables or fruits.

Recent studies of prostate and colorectal cancer show that those eating the most cruciferous vegetables have a much lower risk of both types of cancer—even compared to those who regularly eat other vegetables. In a study of 1,230 men conducted at the Fred Hutchinson Cancer Research Center in Seattle, WA, those eating 28 servings of vegetables a week had a 35% lower risk of prostate cancer, but those consuming just 3 or more servings of cruciferous vegetables each week had a 44% lower prostate cancer risk.

In the Netherlands Cohort Study on Diet and Cancer, a very large study in which data was collected on over 100,000 people for more than 6 years, those eating the most vegetables benefited with a 25% lower risk of colorectal cancers, but those eating the most crucifers did almost twice as well with a 49% drop in their colorectal cancer risk.

The protective power of cruciferous vegetables is even more apparent in those of us whose cleansing systems are sorely challenged: smokers. A study of Chinese women in Singapore, a city in which air pollution levels are often high putting stress on detoxification capacity, found that in non-smokers, eating cruciferous vegetables lowered risk of lung cancer by 30%. In smokers, regular cruciferous vegetable consumption lowered lung cancer risk by an amazing 69%!

How many weekly servings of cruciferous vegetables do you need to lower your risk of cancer? Just 3 to 5 servings—less than one serving a day! (1 serving = 1 cup)

Two key points to help you get the most enjoyment—not only in taste and appearance, but in phytonutrient content—from your crucifers:

  • Choose organically grown cruciferous vegetables. Organically grown foods contain much higher levels of phytonutrients than conventionally grown plants. Plants produce phytonutrients as a protective response against environmental stress. Since conventionally grown plants are protected by pesticides and thus are not exposed to the same level of environmental stress as organically grown plants, they have less need to produce protective phytochemicals.
  • Follow George Mateljan's Healthier Way of Cooking directions. Cooking methods can greatly affect the amount of phytonutrients cruciferous vegetables deliver. Studies show that while raw and steamed broccoli has the ability to produce sulforaphane, microwaved or boiled broccoli does not. And broccoli provides the most sulforaphane if you let it sit for 5-10 minutes after cutting and before steaming, and then steam lightly (no more than 5 minutes).

How Does the Process of Detoxification / Cleansing Work in Our Bodies?

To appreciate the complex dance of health performed by the active constituents in whole foods, a brief overview of the process through which our bodies detoxify or cleanse harmful compounds can be helpful:

Detoxification / Cleansing involves three primary steps, which have been labeled Phase I, II and III.

Phase I is composed of the cytochrome P450 family of enzymes. Although the CYP450s can fully detoxify a few toxins, almost always they only alter toxic compounds slightly, adding a molecule that makes the toxin even more reactive and dangerous, but also serves as a beacon to attract the enzymes involved in Phase II.

Phase II enzymes further change the activated toxin, joining it to other compounds that render it ready for elimination by making it water-soluble.

Phase III proteins, which sit in the external membranes of our cells, then push (efflux) the now water-soluble toxins and cell wastes out of the cell into blood for elimination in the urine, or into the bile for elimination in the feces.

A key point here is that healthy detoxification requires balance among Phases I, II and III.

The Phase I enzymes create compounds that are potentially even more harmful than the original toxin. So, when the activity of these CYP450s is increased, so is the potential for damage—unless the activity of the Phase II enzymes is also increased, so they can promptly process these intermediate products. And finally, the Phase III enzymes must be ready and able to push the resulting water-soluble garbage out of the cell.

Imbalanced detoxification—an upregulated Phase I and downregulated or overloaded Phase II or Phase III—results in the accumulation of highly reactive toxins and garbage inside our cells, a nasty situation that can promote cancer.

Research is now showing that combinations of phytonutrients naturally found in whole foods, particularly the cruciferous vegetables, both increase and balance the activity of Phase I, II and III enzymes. Here are just a few examples of how they work:

Phytonutrients in crucifers trigger the activity of gene response elements. We now know that genes are not activated singly, but in families, each of which is controlled by a gene response element. A gene response element is a very small group of DNA bases that acts like the foreman in a factory and controls the going-to-work of whole crews of genes that then direct the production of proteins needed for various functions, one of which is detoxification. Gene response elements contain information that ensures all the necessary proteins will be made to effectively coordinate and balance detoxification. Phytonutrients in crucifers signal these gene response elements, which then activate the genes needed to produce all the necessary Phase I, II, and III enzymes.

Sulforaphane, a phytonutrient produced when broccoli is cut or chewed, is a good example. Once inside the cell, sulforaphane finds a transcription factor called nrf2, which is bound tightly to a protein called Keap1. Sulforaphane breaks the bond, freeing nrf2, which then travels into the cell's nucleus and binds to a gene response element called the antioxidant response element (ARE). As its name suggests, the antioxidant response element turns on a whole team of genes that produce proteins with antioxidant and balanced cleansing activities.

In addition to sulforaphane, crucifers provide other phytonutrients including crambene and phenylethyl isothiocyanate (PEITC). I3C upregulates Phase I; crambene and isothiocyanates upregulate Phase II. And these compounds enhance each other's beneficial effects. In one study, treatment with a combination of crambene and I3C almost doubled the increase in Phase II enzyme production seen with either compound alone. Of course, broccoli and other crucifers provide this combination naturally.

Indole-3-carbinol (I3C), another phytonutrient in cruciferous vegetables, is metabolized to a variety of cancer-preventive compounds, including diindolylmethane (DIM). I3C induces Phase I and Phase II enzymes that clear carcinogens, enhances repair of damaged DNA by affecting several of the proteins involved in the repair process, and triggers cancer cell cycle arrest and suicide. In addition, both I3C and DIM increase the 2-hydroxylation of estrogens, a process that changes estrogen into a form in which it can no longer promote cancer.

I3C also prevents estrogen from promoting cancer by significantly increasing the production of another benign form of estrogen called the 4-catechol-estrogens. In this form, estrogen can be methylated to form methoxyestrogens (when good supplies of vitamins B6, B12 and folate are around), which also pose no risk for cancer.

While the biochemical steps our bodies follow to cleanse our cells of potentially harmful compounds are quite complex, the bottom line is blessedly simple:

To boost your body's detoxification/cleansing ability, enjoy at least 3 servings each week of cruciferous vegetables, such as broccoli, Brussels sprouts, cabbage, cauliflower and kale.

References

  • Bell MC, Crowley-Nowick P, et al. Placebo-controlled trial of indole-3-carbinol in the treatment of CIN. Gynecol Oncol. 2000 Aug;78(2):123-9. 2000. PMID:10926790.
  • Bland J.S. Mechanisms of metabolism. Lecture presented at the 13th International Symposium on Functional Medicine: Managing Biotransformation: The Metabolic, Genomic and Detoxification Balance Points, sponsored by the Institute for Functional Medicine, www.functionalmedicine.org, April 19-22, 2006, Tampa, FL. 2006.
  • Bland, JS. Pharmacogenomics and the coming of personalized medicine. Lecture presented at the 13th International Symposium on Functional Medicine: Managing Biotransformation: The Metabolic, Genomic and Detoxification Balance Points, sponsored by the Institute for Functional Medicine, www.functionalmedicine.org, April 19-22, 2006, Tampa, FL. 2006.
  • Cohen JH, Kristal AR, et al. Fruit and vegetable intakes and prostate cancer risk. J Natl Cancer Inst. 2000 Jan 5;92(1):61-8. 2000. PMID:10620635.
  • Jeffery, E. Detoxification basics. Lecture presented at the 13th International Symposium on Functional Medicine: Managing Biotransformation: The Metabolic, Genomic and Detoxification Balance Points, sponsored by the Institute for Functional Medicine, www.functionalmedicine.org, April 19-22, 2006, Tampa, FL. 2006.
  • Jeffrey E. Diet and detoxification enzymes. Lecture presented at the 13th International Symposium on Functional Medicine: Managing Biotransformation: The Metabolic, Genomic and Detoxification Balance Points, sponsored by the Institute for Functional Medicine, www.functionalmedicine.org, April 19-22, 2006, Tampa, FL. 2006.
  • Murray M. Altered CYP expression and function in response to dietary factors: potential roles in disease pathogenesis. Curr Drug Metab. 2006 Jan;7(1):67-81. 2006. PMID:16454693.
  • Nho CW, Jeffery E. The synergistic upregulation of phase II detoxification enzymes by glucosinolate breakdown products in cruciferous vegetables. Toxicol Appl Pharmacol. 2001 Jul 15;174(2):146-52. 2001. PMID:11446830.
  • Nho CW, Jeffery E. Crambene, a bioactive nitrile derived from glucosinolate hydrolysis, acts via the antioxidant response element to upregulate quinone reductase alone or synergistically with indole-3-carbinol. Toxicol Appl Pharmacol. 2004 Jul 1;198(1):40-8. 2004. PMID:15207647.
  • Rogan E. The natural chemopreventive compound indole-3-carbinol (I3C): state of science. In Vivo. 2006 Mar-Apr;20(2):221-8. 2006. PMID:16634522.
  • Voorrips LE, Goldbohm RA, et al. Vegetable and fruit consumption and risks of colon and rectal cancer in a prospective cohort study: The Netherlands Cohort Study on Diet and Cancer. Am J Epidemiol. 2000 Dec 1;152(11):1081-92. 2000. PMID:11117618.
  • Zhao B, Seow A, et al. Dietary isothiocyanates, glutathione S-transferase -M1, -T1 polymorphisms and lung cancer risk among Chinese women in Singapore. Cancer Epidemiol Biomarkers Prev. 2001 Oct;10(10):1063-7. 2001. PMID:11588132.

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